Humanized substitutions of Vmat1 in mice alter amygdala-dependent behaviors associated with the evolution of anxiety
Summary: The human vesicular monoamine transporter 1 (VMAT1) harbors unique substitutions (Asn136Thr/Ile) that affect monoamine uptake into synaptic vesicles.These substitutions are absent in all known new belial model mammals, suggesting their contributions to distinct aspects of human behavior modulated by monoaminergic transmissions, such as emo