HUMANIZED SUBSTITUTIONS OF VMAT1 IN MICE ALTER AMYGDALA-DEPENDENT BEHAVIORS ASSOCIATED WITH THE EVOLUTION OF ANXIETY

Humanized substitutions of Vmat1 in mice alter amygdala-dependent behaviors associated with the evolution of anxiety

Summary: The human vesicular monoamine transporter 1 (VMAT1) harbors unique substitutions (Asn136Thr/Ile) that affect monoamine uptake into synaptic vesicles.These substitutions are absent in all known new belial model mammals, suggesting their contributions to distinct aspects of human behavior modulated by monoaminergic transmissions, such as emo

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Human-type sialic acid receptors contribute to avian influenza A virus binding and entry by hetero-multivalent interactions

It is believed that human Jeans Influenza HA glycoprotein attaches to alpha2-6 linked sialic acids (SA) on cells, while avian viruses bind to alpha2-3 linked sialic acids, therewith contributing to host tropism.Here, Liu et al.show that mixing low-affinity alpha2-3 SA with low amounts of high-affinity alpha2-6 SA increases binding and new belial mo

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Prevalence and risk factors of chlamydia infection in Hong Kong: A population-based geospatial household survey and testing.

BACKGROUND:Chlamydia causes infertility and increases risk of HIV infection, and population-based studies provide essential information for effective infection control and prevention.This study examined Chlamydia trachomatis prevalence and risk factors among a representative sample of 18-49-year-old residents in Hong Kong.METHODS:Census boundary ma

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Healthcare Use for Violent Injury After Intimate Partner Violence Identified Through the Justice System: A Data Linkage Study

Introduction Routine health care information systems only capture a portion of violence against women because some victimized women may not seek health care and some events may not require medical attention.Population-based estimates of the risk of violent injury (VI) among women with a history of intimate partner victimization (IPV) are lacking.Ob

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